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Colchicine (Colcrys, Mitigare): using the matches analogy discussed above1, using colchicine can be seen as dampening the uric acid matches. Colchicine does not lower the bodys store of uric acid, but it decreases the intensity of the bodys inflammatory reaction to these crystals

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This can lead to dramatic changes in muscle size and strength, but it also disrupts your body's natural hormone production

In addition, kynurenine reduces the cytotoxicity of NK cells by inhibiting NK cell-activating receptors NKp46 and NKG2D 39

Muscle Aches and Joint Pain: By neutralizing systemic reactive oxygen species (ROS), glutathione helps to lower overall inflammatory burden, which may alleviate the chronic, widespread musculoskeletal pain frequently reported by Long Haulers