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Notably, all these studies are preclinical and involve experimental animal models, encompassing diverse pathways and targets

Control of mild involvement is often achieved with topical treatments, but a specialist consultation becomes appropriate if the symptoms do not respond to first-line therapies

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Selenium is also an essential component of other metabolic systems that deal with oxidative stress, such as the thioredoxin system

Thus, poorer dynamics of phylloquinone and MK4 in the lipid bilayer owing to the lengthy side chains may give rise to their localization within the lipid membrane, suppressing their autoxidation and the consumption of reducing equivalents from NADH or NADPH (Extended Data Fig