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Importantly, this life-prolonging effect is achievable if supplementation duration is life-long or starts late in life, which is a regimen more applicable to humans

The strength of synchronized delivery strategy lies in its ability to consolidate multiple synergistic mechanisms into a single formulation, greatly simplifying the complexity of combination therapy while offering excellent targeting capability and immunostimulatory potential

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Furthermore, biodegradable cationic polyrotaxanes have proven effective in transporting small interfering RNA (siRNA) intracellularly, despite the challenges posed by siRNAs short base-pair lengths and rigid secondary structure, which weaken electrostatic interactions and destabilize polyplexes

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