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In addition, both preclinical and clinical literature often underrepresent females, limiting insights into sex-specific immunometabolic and hormonal modulators of treatment response (Seyedinia et al., 2023

Importantly, although several PROTACs have advanced into clinical evaluation, their exact plasma membrane permeation mechanisms remain incompletely defined

However some women prefer to either manage their symptoms or treat the insulin resistance at the root cause with lifestyle changes such as a healthy diet , exercise and supplements rather than medications

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