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This could be the case for aged and obese mice, where increased ARTD activity has been observed [9,66]

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This is particularly relevant for oral contraceptives, which may have reduced effectiveness during tirzepatide initiation and after each dose increase

The standard dosage for severe deficiency typically starts with 1 mg daily injections, transitioning to weekly and then monthly maintenance doses

It helps in optimising mitochondrial function, which is crucial for maintaining energy at the cellular level