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Application of exogenous LOXL2 to cultured cartilage explants (derived from bovine articular cartilage) and engineered chondrogenic constructs (primary chondrocytes cultured to create a self-assembled structure), which were later implanted into athymic mice, promoted tissue maturation (increased mature crosslinks) and enhanced tensile mechanical properties (Makris et al ., 2014)

Approximately 150 ml of distilled water was added to dissolve the KOH

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weight loss requires a sustained caloric deficit