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Mol Brain Res 29: 211223

Phosphorylated 4E-BP1 releases cap-binding protein eukaryotic translation initiation factor 4E (eIF4E), which counteracts inhibition of protein synthesis by enabling eIF4E to form the eIF4F complex and to participate in cap-dependent translation [37, 38]

Therefore, it is necessary to further explore the precise metformin doses required to change the AMP/ATP ratio and activate AMPK, in order to fully understand the effect of metformin on complex I (Table 4)