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Gene expression programs controlled by canonical and non-canonical TGF- signaling pathways may provide tumor-suppressive or tumor-promoting functions depending on the tumor type and the stage of tumor progression 22

for example, women born in summer months and twins demonstrate a higher likelihood of developing HT, possibly due to seasonal and developmental factors affecting immune programming

They have great potential but need to be used under strict medical supervision and as part of a medical strategy for long-term health.

The interplay of obesity, gut microbiome and diet in the immune check point inhibitors therapy era