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(PubMed) Hess SY

Oral Microbiol Immunol

Alison Steiber, Janos Kerner, Charles L Hoppel

found a significant association between the type 2 ryanodine receptor (RYR2), encoding a stress-induced calcium channel present in many central and peripheral neurons, and CVS [OR = 6.0, (95% CI =1.722)] (55)

MR is strongly recommended as a means of prioritizing drug targets for cardiovascular research, to avoid expensive failures in phase III randomized controlled trials (RCTs) [18, 19] and to identify mechanistic targets of intervention, complementary to RCTs [19]