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Nature Medicine , 25(7), 1231-1241

Maintenance sessions are usually required

This decline manifests as: Impaired recovery from exercise and injury Decreased lean body mass Increased adiposity Poor sleep quality, particularly reduced slow-wave sleep Decreased skin elasticity and wound healing Reduced immune function Critically, these two hormonal systems do not operate in isolation

While the causative efficacy of individual cytokines on the development of certain immunopathogenic parameters in this condition is yet to be fully understood