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In GSTUs, these regions include helix 9 and the segment from roughly the C-terminal end of 4 to the N-terminal end of 5 (Valenzuela-Chavira et al., 2017)

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

This dysfunction permits microbial products, toxins, and excess lipids to reach the liver, triggering immune responses and hepatocellular injury

Liver Detoxification: Concentrated in the liver, glutathione binds to toxins and aids in their removal from the body, detoxifying the liver and helping manage infections like fatty liver disease

In this model, genetically knocking down mir-34c, which is increased by ketamine, is accompanied by increased activity of pkc (Jiang et al., 2018)