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As with all surgeries, there are possible complications, and patients very rarely (less than 5% of the time) experience facial weakness, numbness, double vision, or decreased hearing

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There is a rare effect on the nerves and muscles with long-term use of colchicine, and a blood test from the muscle (CPK) is monitored at approximately six-month intervals in patients taking colchicine on a regular basis

The study found no significant differences in systemic side effects between routes, but noted that injection site reactions were the leading cause of treatment discontinuation (3% of injectable users versus 1% of oral users discontinuing due to GI upset)