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In breast cancer, where EGFR inhibitors such as erlotinib are being used to inhibit the EGFR signaling pathway, IGF-1R confers resistance by forming one half of a heterodimer (see the description of EGFR signal transduction in the erlotinib page), allowing EGFR signaling to resume in the presence of a suitable inhibitor

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EL was calculated by the formula: EL = the initial conductivity (EC1)/the final conductivity (EC2) 100 (Altaf et al., 2022b)