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In the case of HIF2 KO NSCLC cells, employing inhibitors that target the benefit from -KG could be a novel approach in normoxia and in response to irradiation, whereas in patients presenting severe tumor hypoxia, HIF2 inhibitors could be used

7.2 Vedolizumab The latest addition to the biological treatment armamentarium for UC is vedolizumab, which was registered by the EMA and US FDA in 2014