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Mol Cell (2017) 67(4):685701.e6

Greenhaff, J

Auranofin treatment alone was sufficient to induce a modest level of ER stress, seen in upregulation of UPR target genes in the absence of any other ER stress stimulus (Figure 5C)

Contrast induced acute kidney injury and direct cytotoxicity of iodinated Radiocontrast media on renal proximal tubule cells

We speculate that these normal obese subjects may not have insulin resistance or hypogonadism or that this healthy metabolic state of obesity does not cause significant organic damage in a short period of time