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Panels ( e-h ) illustrate the relative intensities obtained from (a-c), subjected to fitting into an exponential decay equation that includes constraints of Y 0 at 1 and plateau at 0

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Metabolic characteristics include: Plasma half-life of 11-12 minutes after either intravenous or subcutaneous administration Very rapid clearance rates of 2.4-2.8 L/min in adult subjects Degradation primarily through peptidase enzymes in plasma and tissues No accumulation observed even with repeated daily dosing The extremely short half-life reflects the peptides susceptibility to proteolytic cleavage at multiple sites along its amino acid sequence

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Behav Brain Res 425:113830 Hautekiet P, Saenen ND, Demarest S, Keune H, Pelgrims I, Van der Heyden J, De Clercq EM, Nawrot TS (2022) Air pollution in association with mental and self-rated health and the mediating effect of physical activity

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