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Hopkins JL, Lan L, Zou L

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It is considered to be a partial agonist of the HCAR1 receptor with maximal stimulation significantly lower than that by L-lactate (Tang et al., 2014), absent ( Synaptic and Vascular Modulation by Lactate The presence of the at that time orphan GPR81 was first demonstrated in brain tissue in 2001 (2)