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The coagulation cascade required for serum preparation triggers massive in vitro platelet activation, artificially releasing abundant platelet-derived exosomes that severely skew and mask the true in vivo circulating exosomal profile (140, 141)

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

Arginine plays a particularly important role as a precursor for nitric oxide, a vasodilator, and key regulator of intestinal motility through relaxing intestinal smooth muscle cells

Novelty-suppressed feeding Novelty-suppressed feeding (NSF) was measured in 24-h food-deprived mice, isolated in a standard housing cage for 30 min before individual testing