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doi:10.1016/j.vetimm.2012.04.001

doi: 10.1002/(SICI)1096-9861(19990322)405:4 3.0.CO;2-P Pubmed Abstract CrossRef Google Scholar View reference in article Keywords dendritic spines, memory and cognition, synaptic activity, synaptic connectivity, electron microscopy, enhanced resolution microscopy, neurodegenerative disease, postsynaptic density Citation Zaccard CR, Gippo I, Song A, Geula C and Penzes P (2023) Dendritic spinule-mediated structural synaptic plasticity: Implications for development, aging, and psychiatric disease

A woman can lose up to 30% of her collagen in the first five years of menopause, leading to sagging skin, wrinkles, and pigmentation

This does not mean AOD 9604 has zero effect

it's the evidence-based threshold where degradation becomes statistically significant