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Alcohol is really, really dehydrating

It is worth noting that the increase in Nrf2 DNA binding activity induced by berberine can be antagonized by PI3K inhibitors and AKT inhibitors

Michalak 2012

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GSH is also a natural ligand for Fe2+ in the labile iron pool (LIP), which is an exchange pool for loosely ligated iron in neurons (Hider and Kong, 2011), and glutathione binds Fe2+ in LIP to prevent iron oxidation, which not onlymaintains Fe2+ solubility but also prevents Fe2+ from acting as a catalyst to generate a potent oxidant, hydroxyl radical, from physiologically available hydrogen