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These models have contributed to our understanding of the mechanisms underlying -syn toxicity, such as membrane binding, protein quality control and autophagy, calcium transport, protein phosphorylation, vesicular trafficking and recycling, cell death and cell senescence [215, 216]

Schreiberov M, Vlaskov L, Vlek O, Mejdov J, Horlek J, Bieser JJA

Molecular cloning and characterization of a gamma-glutamylcysteine synthetase gene from Chorispora bungeana

Immunologically mediated thrombosis may also play a role, with reports of the presence of anticardiolipin and antiphospholipid antibodies, as well as lupus anticoagulant (73, 79)

The absence of regulatory guidelines around dosage, frequency, and duration further complicates safety evaluations