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13-16 weeks : After assessment, your doctor will escalate the dosage to 8 mg once weekly for the next 4 weeks 17-21 weeks : If your body tolerates 8 mg for 4 weeks, your doctor will increase the dose to 12 mg once weekly onwards

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No controlled human-lifespan trial was identified

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When a drug binds extensively to components outside the plasma, such as proteins in muscle or lipids in adipose tissue, only a small fraction of the total drug in the body remains in the plasma to be measured

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Metformin ameliorates core deficits in a mouse model of fragile X syndrome

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