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Collodel G, Moretti E, Noto D, Iacoponi F, Signorini C

The study planned to include 200 patients with type 2 diabetes who were not on any antidiabetic drugs in the 90 days prior to Visit 1 (except in certain clinical situations, such as acute illness, hospitalization, or elective surgery, short-term (14 days) use of insulin)

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Conclusions Our findings reveal a growing trend toward digital integration in rare disease trials to support decentralized, scalable, and patient-centered research models

Both approaches commonly act on key signaling pathways, including Nrf2, NF-B, and AMPK, indicating a potential for synergistic interaction