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In summary, RCTs remain essential for establishing efficacy and internal validity, but their limited generalizability, high cost, and ethical constraints restrict their ability to answer all questions relevant to patient care

While antioxidant response enzymes are well-characterized transcriptional targets of NRF2, it is recently becoming clear that NRF2 also supports cellular detoxification through metabolic rewiring to support the antioxidant systems

Western blot analysis showed that FADS knockdown led to increased phosphorylation of TBK1 (Ser172) and IRF3 (Ser396) (Fig

These are logical applications given the mechanisms involved, but both require further study