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TGF-1 activates Smad2/3, PI3K/Akt, ERK1/2, GSK-3 and/or p38MAPK signalling to induce pulmonary fibrosis and EMT

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A broad panel of antibodies was employed, including those for FOXO4, p53, phospho-p53, p21, p16, cleaved-Caspase3, BAX, BCL-2, testosterone synthesis enzymes (3-HSD, CYP11A1, CYP17A1), and various SASP factors (IL-1, IL-6, TNF-, TGF-)

The effect of repurposed drugs, such as metformin and CoQ10 in SLE treatment has been well investigated (171)

For example, the protein may interact with certain protein partners with the switch in one redox state, and with other protein partners when the switch is in the alternate redox state