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of workers Exposure Effects Defects in study Reference components exposed duration Acute MEK 1174-1655 mg/m 3 (389-561 ppm), 2 few hours eyes watering, gastric measurements of work Smith & acetone 785-1178 mg/m 3 (330-495 ppm) distress, fainting, environment limited Mayers convulsions, twitching, to post exposure (1944) headache, spinal pressure Chronic MEK 561-885 mg/m 3 (190-300 ppm), 13 1 year or fatigue, frequent headache, measurements of work Lee & toluene 139-177 mg/m 3 (37-60 ppm), more dizziness, incoordination, environment limited Murphy MIBK 37-41 mg/m 3 (9-14 ppm) skin rashes, vomiting to post exposure (1982) MEK 30 mg/m 3 (10 ppm), toluene 2 2 and 6.5 paraesthesis in extremities, measurements of work Dyro 94-488 mg/m 3 (25-130 ppm) years reduced motor nerve conduction environment limited (1978) velocity, weakness in to post exposure individuals exposed for long periods, improvement following cessation of exposure MEK 62-51 mg/m 3 (21-180 ppm), acetone 1 1 year altered consciousness and measurements of work Dyro 86-595 mg/m 3 (36-250 ppm) EEG, reduced motor nerve environment limited (1978) conduction velocity to post exposure MEK 142 mg/m 3 (48 ppm), isobutanol 8 not stated headache, dizziness, fatigue, measurements of work Binaschi 67 mg/m 3 (23 ppm), MIBK 16 mg/m 3 (4 ppm), depression, significant environment limited et al

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For differential accessibility analysis, BAM files were merged by sample using Samtools before calling peaks with MACS v2.2.9.1 109