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This decyanation process is demanding: Although the amount of cyanide is considered toxicologically insignificant, humans must remove and detoxify the cyanide molecule, reduce the cobalamin to its usable +1 oxidation state, and then enzymatically convert the cobalamin into one of two metabolically active coenzyme forms

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In particular, they demonstrate reduced NF-B interaction and decreased transrepression of proinflammatory and apoptotic genes compared to other isoforms ( in vivo studies of GR mRNA/protein isoform overexpression are required to confirm GR isoform-specific functions