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Mechanism of hyperammonemia in patients with GDH-HI In hepatocytes, elevated GDH activity leads to an increased rate of glutamate decomposition to ammonia

Pregnant Wistar rats received quercetin at 50 mg/kg orally from gestational day 6.518.5, while autism-like features were induced by a single oral dose of VPA (800 mg/kg) on gestational day 12.5