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Therapeutic Use Exemption Program It should be noted that for athletes who have a legitimate medical reason for using a prohibited substance or method that is on the List, they can apply for a Therapeutic Use Exemption (TUE) to determine whether they meet the criteria outlined in the International Standard for Therapeutic Use Exemptions (ISTUE)

Koleilat A, Driscoll CLW, Schimmenti LA, Poling GL

New England Journal of Medicine 1991

Climacteric 15 (1), 3035

6 Conclusion Persistent barriers in solid tumor therapy, including uneven drug penetration, hypoxia- and acidosis-associated resistance and local immunosuppression, reflect structural and functional imbalances in the TME