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There is a wide range of MRS sequences available to measure in vivo brain GSH, and while the current studies in AD and MCI suggests that MEGA-PRESS is a good candidate for technique standardization, recent advances in MEGA-PRESS have also allowed for simultaneous measurements of pairs of compounds such as GSH/-aminobutyric acid and N -acetyl aspartate/ N -acetyl aspartyl glutamate in one acquisition [96, 97]

Vitamin C, also known as ascorbic acid, is a water-soluble antioxidant that can neutralize ROS in the aqueous environments of the body, such as the cytoplasm and extracellular fluids

Larabi, for their help with protein expression, purification, crystallization and X-ray diffraction analyses

Data were collected from the FL1 channel