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According to an investigation from the Institute for Health Metrics and Evaluation (IHME) that was written about in The Lancet , 153 million individuals globally will have Alzheimers disease by the year 2050 [98]

To validate our results and explore the underlying mechanisms of those predicted genes, we conducted the protein functional analysis and pathway enrichment analysis using Reactome database ( which is a relational database of signaling and metabolic molecules ( To check the gene expression pattern of those interacting proteins, we used the Genotype-Tissue Expression (GTEx) database ( Furthermore, to validate the predictive associated gene, we studied their protein or gene function based on UniProt database ( and published literature

10.1126/science.1195227 21 BurrJ.VivonaS.DiaoJ.SharmaM.BrungerA

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