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When copper handling is impaired, reactive copper may increase oxidative stress and place greater demand on glutathione and other antioxidant defenses

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134 Mutant IDH-targeted therapy and a number of important recent pre-clinical and clinical studies in IDH-mutant solid tumors have been extensively reviewed elsewhere, 147 and listed in Table 2

Second, in vitro co-culture assays demonstrated that moderate-mutant primary tumor cells exhibited enhanced neutrophil recruitment, whereas high-mutant cells showed recruitment levels similar to or even lower than controls (Extended Data Fig

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