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In advanced stages, chronic venous disease can cause leg swelling, changes in skin appearance and texture, and ulcers

10.3390/antiox10091413 Antioxidants 87 SalazarK.MartinezF.Perez-MartinM.CifuentesM.TriguerosL.FerradaL.et al (2018)

This highlights the crucial role of NOX4 not only in inducing cellular oxidative stress but also in regulating iron-dependent cell death, indicating its importance in both normal physiological and pathological conditions