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Combined use produces approximately 30-60% better outcomes versus either peptide alone according to community reports

Several molecular mechanisms have been identified that may explain resistance and increased invasion after anti-angiogenic therapy in glioma, including mesenchymal transition of tumor cells, up-regulation of pro-angiogenic factors, activation of MET and up-regulation of MMPs [293,294,295,296]

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doi:10.1016/j.yjmcc.2022.08.002

GRAS simply means the FDA agrees that the substance, at intended use levels as a food additive or supplement, is safe based on common use history or expert opinion and does not pose acute toxicity concerns