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Although there used to be a dichotomy paradigm of having a protective proinflammatory response at early stages and then a shift to anti-inflammatory responses at later stage, recent research indicated that there is no such distinction in immune reopposes to mycobacterial or other intracellular infections and there is cross-regulation of pro and anti-inflammatory responses at different stages ( Evaluation of cytokines secretion in mice model indicated that although only three weeks passed after inoculation with wild-type MAP, almost all the proinflammatory cytokines including IFN, IP-10, IL-6, KC, MCP-1, MIG, MIP-1, RANTES, TNF had concentrations higher than 200 pg/ml in serum