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Quite recently, some edaravone analogs with improved BBB penetration and overall efficacy were developed

Since treatment is administered intravenously vs

The steroid group, in particular, showed early improvements with VAS scores at rest enhancing from the initial week

For example, previous research has identified Coco, a secreted antagonist of TGF- ligands, which can promote self-renewal and cause recurrence by inhibiting lung-derived BMP dormancy signaling [228]

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