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the stability of the protein is also given in mannitol-free preparations in the same way, but the solutions are then less well tolerated due to their lack of isotonicity

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This pathway induces the expression of various downstream target proteins, such as haem oxygenase 1 (HO-1), superoxide dismutase 1 (SOD1), quinone oxidoreductase 1 (NQO1), and glutamylcysteine synthetase (GCS), among others [97]

10.1016/j.biomaterials.2015.04.060 157 WangY.WuM.GuL.LiX.HeJ.ZhouL.et al (2017)

L-arginine converts to citrulline and nitric oxide through NOS activity, while citrulline converts back to arginine through the kidney-based recycling pathway