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On the other hand, CD38 ligation by daratumumab leads to aggregation of protein:antibody complexes, formation of distinct polar aggregates, and subsequent release of microvesicles (MVs)

Licensed clinicians evaluate whether specific therapies are appropriate as part of a personalized care plan

If the patient had surgery to remove some or all of the parathyroid glands in their neck, or had sections of their intestine removed, or are unable to take calcium supplements they should tell their doctor

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Acknowledgements We would like to thank the Laboratory of Hematology (GIGA-ULige), the Centre for Protein Engineering (ULige) and the Molecular Imaging and Therapy Laboratory (Vrije Universiteit Brussel) for their excellent technical assistance in our different projects