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Carnitine supplementation in high-fat diet-fed rats does not ameliorate lipid-induced skeletal muscle mitochondrial dysfunction in vivo

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The accumulated ROS in cells interacts with Ca 2+ , increasing the permeability of the endoplasmic reticulum membrane by promoting redox modification of Ca 2+ channels, leading to the release of Ca 2+ reserves from the endoplasmic reticulum into the cytoplasm and inducing Ca 2+ overload (91)

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