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Multifunctionality and Medical Application Review (2025): A comprehensive literature and patent review published in 2025 summarised BPC-157s biological activities across tissue injury, inflammatory bowel disease, and CNS disorders

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Unlike class A GPCRs (such as beta-adrenergic, opioid, and histamine receptors), which have been successfully targeted by small molecules for decades, class B GPCRs possess a large N-terminal extracellular domain (ECD) of approximately 120-160 amino acids that plays a critical role in ligand recognition and receptor activation

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