zinc supplementation increased glutathione synthase ncbi Clinical and biochemical understanding of interaction during liver diseases: A paradigm shift The Important Role of Zinc

Although apoptosis and pyroptosis can occur simultaneously under certain conditions, which mode that predominates is substrate-dependent

The key transcription factors that regulate gene expression are NF-E2-related factor 2 (Nrf2) via the antioxidant response element (ARE), AP-1, and nuclear factor kappa B (NF-B)

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AICART: aminoimidazolecarboxamide ribonucleotide transferase BHMT: betaine-homocysteine methyltransferase CBS: cystathionine -synthase CTGL: -cystathionase DHFR: dihydrofolate reductase DMGD: dimethylglycine dehydrogenase DNMT: DNA-methyltransferase FTD: 10-formyltetrahydrofolate dehydrogenase FTS: 10-formyltetrahydrofolate synthase GCS: -glutamylcysteine synthetase GDC: glycine decarboxylase (glycine cleavage system) GNMT: glycine N-methyltransferase GPX: glutathione peroxidase GR: glutathione reductase GS: glutathione synthetase MAT-I: methionine adenosyl transferase I MAT-III: methionine adenosyl transferase III MS: methionine synthase MTCH: 5,10-methenyltetrahydrofolate cyclohydrolase MTD: 5,10-methylenetetrahydrofolate dehydrogenase MTHFR: 5,10-methylenetetrahydrofolate reductase NE: non-enzymatic conversion PGT: Phosphoribosyl glycinamidetransformalase SAAH: S-adenosylhomocysteine hydrolase SDH: sarcosine dehydrogenase SHMT: serinehydroxymethyltransferase TS: thymidylate synthase Metabolites

1 Mechanism of total glutathione quantification Fig