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doi: 10.1016/j.jare.2023.10.008 65 ChoiEHParkSJ

It appears as though HFD-stimulated excess ROS production (Vial et al., 2011) can precede observable weight gain and insulin resistance (Matsuzawa-Nagata et al., 2008), indicating that oxidative stress might be a result of the diet itself and not a consequence of excess lipid accumulation

Cu + can also bind to transcription factors in the cell nucleus, thereby affecting gene expression and subsequent protein synthesis (21)

1 The thyroid gland is particularly rich in selenium, wherein deiodinases convert thyroxine (T4) into its active form triiodothyronine (T3), thereby regulating metabolism at both systemic and cellular levels