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The formation of methemoglobin from hemoglobin within red cells is an ongoing oxidative process that results from exposure of hemoglobin to a variety of highly reactive molecules (oxygen free radicals), produced during normal cell metabolism [4]

all 52 patients completed the study

doi: 10.1126/science.1227670

Zhou NB, Zhu YQ, Yin QH (2010) Determination of ergothioneine in Agaricusbisporus by HPLC

Correspondingly, metabolomics approaches on animal models and human cohort samples have been deployed for pathway identification and novel predictive/diagnostic/prognostic biomarker discovery in CVDs 29,30,31,32 , and for improving disease classification, risk stratification, and personalized medicine