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However, this method has also a disadvantage such as high production costs of (R)-4-chloro-3-hydroxybutyrate derivate, and a difficulty of application thereof to industrial-scale production in that the reaction must be carried out under high- temperature and high-pressure conditions

However, the prevention of muscle dysfunction with established treatment protocols is primarily symptom-oriented and includes physical therapy and exercise, but no specifically approved pharmacologic interventions are currently available [4,5]