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G.DahiyaR

Jefferies et al., 1994

This revealed 38 variants that were both identified in our screen and characterized in the database as non-functional, damaging mutations (Fig

When levels are low, cells are left more vulnerable to oxidative damage accelerating the aging process and increasing the risk of various chronic diseases

Here, we found that REST was upregulated in AKI patients, mice, and RTECs, which was positively associated with the degree of kidney injury, while renal tubulespecific knockout of Rest significantly alleviated AKI and its progression to chronic kidney disease (CKD)