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At steady state, active BACE1 is predominantly found in the endosomes, where a lower pH (around pH 4.5) is optimal for -secretase activity (Vassar et al, 1999), although some studies have also reported BACE1 activity at the TGN (Thinakaran et al, 1996

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Melatonin synergistically enhances docetaxel induced endoplasmic reticulum stress to promote apoptosis by suppressing NF-B activation in cervical cancer

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Sublingual troches / lozenges: 50200 mcg per troche, 12 times daily , dissolved between cheek and gum for 1520 minutes