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These results suggested a state of high oxidative stress in the interior of the herniated nucleus pulposus, which likely accelerates disc degeneration

Respective samples were analysed as described in HPLCMS/MS analysis for ADME and PK studies section in the Supplementary Information

doi: 10.1158/0008-5472.Can-15-1545 [DOI] [PubMed] [Google Scholar] 112

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MACROPHAGE SCAVENGER RECEPTOR (SR-AI) In 1979, Brown and Goldstein demonstrated that macrophages had specific binding sites for acetylated LDL (AcLDL) that allowed uptake of this modified LDL even in the presence of high cellular cholesterol levels (298)