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Despite the efficacy of mTOR inhibitors in reducing primary tumor growth and CSC activity, lung metastasis remain resistant to treatment, indicating distinct mechanisms driving metastasis compared to primary tumor growth in ER + mammary carcinomas exposed to high collagen density [15]

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NAD+ provides a promising therapy for those suffering from addiction, depression, & neurocognitive disorders

To confirm this finding, we selected tubular ER markers based on published RNA sequencing data (Supplementary Fig 1c) and conducted immunohistochemistry on spinal cord cross-sections from P14 mice