These findings suggest that defects in the remethylation and transsulfuration pathways may contribute to the elevated homocysteine levels observed in children with autism spectrum disorder.35 Epidemiological studies have found that individuals experiencing major depressive disorder and bipolar disorder have elevated plasma levels of homocysteine and deficient plasma levels of folate and vitamin B12.35 The effect of reducing plasma homocysteine levels on the symptomology of these neurological disorders has not been well-studied, and clinical trials investigating associations between folic acid and vitamin B12 supplementation and mood disorders have provided inconsistent results
There is a large microbial community in the human gut, and at least 20% of small molecules in the human blood are products of the microbiome, which plays a vital role in our physiology and metabolism (Rook et al., 2017)
Many users of NAD+ Nasal Spray notice steadier energy and less brain fog for the same reason
1 Vitamin D exerts its biological actions through vitamin D receptors and hence plays its role through the regulation of gene expression in places where its receptors exist, such as the endocrine system
Biochem Biophys Res Commun 426:643648 Medeiros DM, Plattner A, Jennings D, Stoecker B (2002) Bone morphology, strength and density are compromised in iron deficient rats and exacerbated by calcium restriction