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Once they reach the required depth, buoyancy is stabilised so that it becomes neutral

Taking B12 too close to bedtime can be stimulating for some people and may make it harder to fall asleep or stay asleep. If you notice any change in your sleep after starting B12, simply move your dose earlier in the day and track how you feel

As Professor Carmel highlights: Residual disability, estimated to affect 6% of neurologic patients, is the most feared outcome of cobalamin deficiency and is likely to persist if still present after 6 to 12 months of treatment

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